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BackgroundHeavy metal contamination has become a serious issue in this century especially detected in fish organs. Due to the presence of radioactive compounds in agricultural and sewage effluent, which destroys aquatic ecosystems, threatening human livelihoods. Health hazards associated with low and high consumption consumers assessed in five commercial fish species collected from Hurghada City, Egypt, during winter and summer, 2020. Atomic absorption spectrophotometer technique used for determination heavy meals in different organs and expressed as μg/g wet weight.ResultsHeavy metal concentrations in muscle ranged between:(0.054–0.109), (0.260–1.043), (0.264–0.897), (5.895–11.898), (0.381–0.970), (13.582–29.133) and (0.332–0.589) µg/g for Cd, Pb, Mn, Zn, Cu, Fe and Ni respectively, which were lower than those of gills and liver. These concentrations were within WHO, FAO/WHO, and EU standards. Consumption of edible species was lower than the (TDIs) established by the (JECFA) and Egyptian Standards. Even though THQ and TTHQ values were < 1 while, in children with highly consumer were> 1.ConclusionThis study concluded that intake of Red Sea fish is safe for human health. It is critical for consumers to be aware of the consequences of excessive fish consumption, particularly children with highly consumer, which represent possible health risks. 相似文献
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《Vaccine》2020,38(39):6141-6152
Influenza vaccination is considered the most valuable means to prevent and control seasonal influenza infections, which causes various clinical symptoms, ranging from mild cough and fever to even death. Among various influenza vaccine types, the inactivated subunit type is known to provide improved safety with reduced reactogenicity. However, there are some drawbacks associated with inactivated subunit type vaccines, with the main ones being its low immunogenicity and the induction of Th2-biased immune responses. In this study, we investigated the role of a single-stranded RNA (ssRNA) derived from the intergenic region in the internal ribosome entry site of the Cricket paralysis virus as an adjuvant rather than the universal vaccine for a seasonal inactivated subunit influenza vaccine. The ssRNA adjuvant stimulated not only well-balanced cellular (indicated by IgG2a, IFN-γ, IL-2, and TNF-α) and humoral (indicated by IgG1 and IL-4) immune responses but also a mucosal immune response (indicated by IgA), a key protector against respiratory virus infections. It also increases the HI titer, the surrogate marker of influenza vaccine efficacy. Furthermore, ssRNA adjuvant confers cross-protective immune responses against heterologous influenza virus infection while promoting enhanced viral clearance. Moreover, ssRNA adjuvant increases the number of memory CD4+ and CD8+ T cells, which can be expected to induce long-term immune responses. Therefore, this ssRNA-adjuvanted seasonal inactivated subunit influenza vaccine might be the best influenza vaccine generating robust humoral and cellular immune responses and conferring cross-protective and long-term immunity. 相似文献
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Zhihang Peng Changjun Bao Yang Zhao Honggang Yi Letian Xia Hao Yu Hongbing Shen Feng Chen 《南京医科大学学报(英文版)》2010,(3):207-214
This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course.Then the paper presents a weighted Markov chain,a method which is used to predict the future incidence state.This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable.It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal.Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province.In summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology. 相似文献
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目的分析泰州市居民慢性病防治健康素养水平及其影响因素。方法在2018年6月—2019年5月间经多阶段分层整群随机抽样选取泰州市2022名常住居民开展慢性病防治健康素养相关问卷调查,分析调查结果。结果2022份问卷回收有效问卷2010份;以“儿童青少年也可能发生抑郁症”正确率89.0%、“超重或肥胖者易患的病”正确率80.3%占据前两名;慢性病防治健康素养水平相关因素包括地区,年龄,文化等,差异有统计学意义(P<0.05),性别方面差异无统计学意义(P>0.05);经Logistic回归分析显示,影响慢性病防治健康素养影响因素主要包括地区、年龄、学历、职业及家庭收入,差异有统计学意义(P<0.05)。结论泰州市居民慢性病防治健康素养在蔬菜水果、儿童抑郁症及肥胖者易患病等方面水平较高,而在骨质疏松相关知识了解程度则较低,影响因素包括地区、年龄、学历、职业及家庭收入。 相似文献
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目的分析不同建成环境特征对江苏省南京地区儿童青少年体力活动水平的影响,为提高儿童青少年体力活动水平提供科学依据。方法于2018年5—6月采用现况研究设计,使用多阶段整群随机抽样方法,选择南京市12个行政区4~12年级学生(9~17岁儿童青少年)共4401人进行问卷调查,采用国际上通用体力活动居住环境量表(PANES)来评价建成环境的特征;采用多水平logistic回归方法分析不同建成环境特征对南京市儿童青少年体力活动水平的影响。结果调查的4401名儿童青少年体力活动水平充足比例为21.1%(930/4401)。以学校为随机因素,在调整了年龄、性别以及父母最高文化水平后,多水平logistic回归分析结果显示,社区道路具有人行道(OR=1.40,95%CI=1.10~1.78)、社区具有隔离的自行车车道(OR=1.37,95%CI=1.12~1.67)对儿童青少年体力活动水平具有促进作用。以小学、初中、高中进行分层,结果显示,初中组社区具有隔离的自行车车道(OR=1.59,95%CI=1.11~2.27)以及高中组看到社区居民积极锻炼身体(OR=1.88,95%CI=1.05~3.39)对儿童青少年体力活动水平具有促进作用。结论不同建成环境特征能够明显影响儿童青少年体力活动水平,建成环境作为影响儿童青少年体力活动水平的一个可控因素应引起更多关注。 相似文献
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《Vaccine》2022,40(44):6397-6403
Mumps virus (MuV) is highly neurotropic and neurovirulent, hence, the neurovirulence of virus seeds used in the production of mumps vaccines must be tested. The previous neurovirulence evaluation method involves measuring the area of the cavity in the Lewis neonatal rat brain caused by MuV through paraffin sectioning and hematoxylin-eosin (HE) staining. However, the processes of paraffin sectioning and HE staining are time consuming and complicated. To solve this problem, in this study, a vibratome sectioning system was first deployed to evaluate MuV neurovirulence in the rat brain instead of paraffin sectioning and HE staining. The results showed that the vibratome sectioning method could assess the neurovirulence potential of MuV more objectively and efficiently. In addition, the effects of different MuV doses and the ages of the rats in days on this evaluation method were explored. The results indicate that MuV at no less than 10 50 % cell culture infective dose (CCID50) could cause obvious cavity formation in 1-day-old rat brains. The neonatal rat model developed in this study could evaluate the neurovirulence of different MuV strains with high sensitivity and good repeatability. 相似文献